Festkolloquium zu Ehren des 80. Geburtstags von Prof. Dr. Erich Sackmann
Bitte gesonderte Anfangszeit beachten!
Prof. Dr. Rudolf Merkel
Institute of Complex Systems, ICS-7: Biomechanics, Forschungszentrum Jülich:
‘‘Cellular reactions to external forces’’
Throughout the organism almost all tissues experience mechanical strain of sizeable magnitude that often is important to their organization and development. To unravel the underlying signal sensing and processing an in vitro model consisting of cells cultivated on stretchable substrates was introduced. Here, I will show how this system can be used as quantitative tool to unravel the contributions of the different cytoskeletal systems and to quantify the ‘mechanosensing potential’ of individual molecules.
Prof. Dr. David Andelman
School of Physics and Astronomy, Tel Aviv University, Israel:
‘‘One hundred years of electrified interfaces: past, present and future’’
The Poisson-Boltzmann theory is a mean-field description of ionic solutions and charge interfaces, and it has been instrumental during the last century to predict charge distributions and interactions between charged macromolecules. While the electrostatic model of charged fluids, on which the Poisson-Boltzmann description rests, and its statistical mechanical consequences have been scrutinized in great detail, much less is understood about its probable shortcomings when dealing with various aspects of real physical, chemical and biological systems. After reviewing the important results of the Poisson-Boltzmann theory, I will discuss several modern extensions and modifications as applied to ions in confined geometries. They include fluctuations and correlations leading to a surprising attraction of like-charged surfaces, the importance of the ion-dipole interaction in aqueous solutions, and finite size of ions and other short-range interactions on ionic profiles and surface tension of electrolyte solutions.