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Biophysics of Macromolecules – Syllabus

SYLLABUS

18th Oct. Introduction to bio-macromolecules (BPM_01.pdf)
Overview, "the inner life", biophysics: experiments/models/concepts, the ideal chain

21st Oct. Protein conformation - the peptide bond (BPM_02.pdf)
The peptide bond, properties of amino acids, Ramachandra plot (see also Sackmann Chap 5.1 and 6.1-6.2)

25th Oct. Protein conformation - physical interactions (BPM_03.pdf) (Tafelbild03.pdf)
Electrostatics, Poisson-Boltzmann, dipolar, VdW, H-bridges (see also Sackmann Chap 6.3-6.4)

28th Oct. Protein folding - hydrophobic collapse (BPM_04.pdf)
Hydrophobic interaction, Afinsen hypothesis (see also Sackmann Chap 6.5-6.6, 7.1)

1st Nov. Holiday

4th Nov. Protein folding - Helix-coil transition (BPM_05.pdf) (Tafelbild05.pdf)
Levinthal paradox, folding funnel, helix-coil transition (see also Sackmann Chap 7.1-7.2)

8th Nov. X-ray protein crystallography

11th Nov. Force induced protein unfolding (BPM_07.pdf)

15th Nov. Force-extension Curves (BPM_08.pdf) (Tafelbild_08.pdf)
entropic spring, freely jointed chain model,WLC

18th Nov. Cytoskeleton filaments (BPM_09.pdf)

22nd Nov. Actin polymerization (BPM_10.pdf)

25th Nov. canceled

29th Nov. Actin Treadmilling (BPM_11.pdf)

2nd Dec. Thermal ratchets

6th Dec. Molecular Motors I (linear motors (BPM_13.pdf)

9th Dec. canceled

13th Dec. Molecular Motors II (Muscle) (BPM_14.pdf)

16th Dec. Molecular Motors III (rotation motors) (BPM_15.pdf)

20th Dec. Crowded and disordered environments (BPM_16.pdf)

10th Jan. Viscoelasticity/Polymer Dynamics (BPM_17.pdf)

13th Jan. canceled

17th Jan. Non-Newtonian Fluids

20th Jan. DNA elasticity (BPM_19.pdf)

24th Jan. DNA motors and viruses (BPM_20.pdf)

27th Jan. Structure of the genome - Chromatin (BPM_21.pdf)

31st Jan. DNA nanotechnology

3rd Feb. PROBEKLAUSUR (Vorlesung und Übungen entfallen!)

7th Feb. final lecture

10th Feb. KLAUSUR (Musterlösung) (Ergebnisse)